Chronic kidney disease (CKD) disproportionately impacts under-resourced and minoritized communities, with stark income and ethnic disparities in the U.S. Because CKD develops silently over decades and often isn’t diagnosed until late stages, effective prevention requires studying early-stage CKD in high-risk, asymptomatic individuals. Building trust within these communities—who often have justified mistrust of healthcare systems—is essential for successful research and intervention efforts.